Toxic Effects Of Adipic Acid Dioctyl Ester

Adipic Acid Dioctyl Ester Toxicity Test Data No. Toxicity Type Test Method Test Object Dosage Toxicity 1 Acute Toxicity Oral Rat 9100 mg/kg Detailed Effect No other value except lethal dose is reported 2 Acute Toxicity Intraperitoneal Injection to Rat>50 mL /kg Detailed effects No values other than lethal dose are reported 3 Acute toxicity Intravenous rat 900 mg/kg Detailed effects no other value than lethal dose reported 4 Acute toxicity Oral mouse 15 mg/kg Detailed effects are not reported except Values other than lethal dose5 Acute Toxicity Intraperitoneal Mice >100 mg/kg Detailed effects No values other than lethal dose are reported6 Acute toxicity Skin surface Rabbit 16 mL/kg Detailed effects No other value than lethal dose reported 7 Acute toxicity Intravenous injection rabbit 540 mg/kg Detailed effects No value other than lethal dose reported 8 Acute toxicity Oral mammal 15 mg/kg Detailed effect No value other than lethal dose reported 9 Chronic toxicity Oral rat 25200 mg /kg/3W-C 1. Hematotoxicity - changes in serum components (such as TP, bilirubin, cholesterol) 10 Chronic toxicity Orally administered to rats 191 mg/kg/13W-C 1. Hepatotoxicity - changes in liver weight 2. Nutritional and metabolic system toxicity - weight loss or decrease in body weight gain rate 3. Biochemical toxicity - inhibition or induction of hepatic microsomal mixed function oxidases (dealkylation, hydroxylation, etc.) 11 Chronic toxicity Oral administration of 168 mg to mice /kg/14D-C 1. Chronic disease-related toxicity - death 12 Chronic toxicity oral administration of 280 mg/kg/13W-C in mice 1. Hepatotoxicity - other changes 2. Hepatotoxicity - changes in liver weight 3. Biochemical toxicity ——Inhibition or induction of liver microsomal mixed function oxidase (dealkylation, hydroxylation, etc.) 13 Mutatoxicity Escherichia coli 25 ug/well 14 Mutatoxicity oral administration to rats 378 umol/kg 15 Mutatoxicity oral administration to mice 2 mg/well kg 16 Mutatoxic intraperitoneal injection of mice 1000 mg/kg 17 Mutatoxic hamster ovary 400 mg/L 18 Carcinogenicity oral administration of mice 1038 mg/kg/2Y-C 1. Carcinogenicity - carcinogenic (according to RTECS standard) 2. Liver Toxicity—Tumor 19 Carcinogenicity in mice Oral administration of 2163 mg/kg/2Y-C 1. Carcinogenicity—Carcinogenicity (according to RTECS standards) 2. Hepatotoxicity—Tumor 20 Carcinogenicity in mice Oral administration of 1048 mg/kg/2Y-C 1. Carcinogenicity - carcinogenic (according to RTECS standard) 2. Hepatotoxicity - tumor 21 Reproductive toxicity Intraperitoneal injection of 15 mg/kg in rats, 5-15 days after female conception 1. Reproductive toxicity - Fetal toxicity (such as fetal dysplasia, but not death) 22 Reproductive toxicity Intraperitoneal injection of 30 mg/kg in rats, 5-15 days after female conception 1. Reproductive toxicity - other developmental abnormalities.

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